Is mitochondrial disease a secondary effect in RS?
• Morphologic research is directed towards identifying possible deficiencies in neurotrophic factors which could initiate the changes which appear to be an arrest of brain development. Back to Top Epidemiology And Survival The prevalence of Rett syndrome is 1 per 22,800 (0.44/10000) females aged 2–18 years of age as determined in the Texas Rett Syndrome Registry. Incidence values are limited, varying from 0.43-0.71/10,000 females in France to 1.09/10,000 females in Australia. Rett syndrome has been reported in all races and ethnic groups. Rett individuals have an estimated 70% survival at age 35 years; this contrasts sharply with an estimated 27% survival at 35 years for severely retarded individuals. The majority of deaths in Rett syndrome are either sudden and unexpected or secondary to pneumonia.
