Is metformin therapy safe in pregnancy and breast feeding?
The use of Metformin in pregnant patients with polycystic ovarian disease seems to be accepted among the common clinician based on small studies although views remain varied Curr Opin Obstet Gynecol. 2004 Jun;16(3):245-50 in the absence of randomised control trials around which the whole world revolves these days. While miscarriage and gestational diabetes seem to be more common in polycystic ovary syndrome, evidence that these can be improved with metformin is awaited from trials in the future. Good old personal experiences supported by peer group experiences should still find a strong place in decision making to use these drugs while awaiting further evidence through trials. (personal view) Remembering that “Absence of Evidence is not Evidence of Absence”, is crucial to avoid denying the benefits of drugs that are “more likely” to be beneficial than harmful based on current evidence, while waiting years for delayed evidence to come through at the mercy of the whims and competitions o
