Is Knee Chondrocalcinosis Associated with Progressive Cartilage Damage?
February 2007 – Jon Giles, M.D. A strong association between chondrocalcinosis, resulting from calcium pyrophosphate dihydrate (CPPD) deposition, and knee osteoarthritis (OA) is firmly established. However, despite the association, a causative pathogenic role for CPPD crystals on the progression of articular degeneration in the knee has not been definitively demonstrated. Here, Neogi et al (Arthritis Rheum 2006; 56(6): 1822) investigate the effect of chondrocalcinosis on the progression of knee OA using magnetic resonance imaging (MRI).
