Is it safe to use Ventavis® (iloprost) Inhalation Solution in combination with other PAH therapies?
A. Safety in combination has only been established to date in combination with an endothelin receptor antagonist. In a small clinical trial (the STEP trial Safety and Pilot efficacy in combination with [an ERA] for Evaluation of Pulmonary arterial hypertension), safety trends in patients receiving concomitant bosentan and iloprost were consistent with those observed in the larger experience of the Phase 3 study in patients receiving only iloprost.1 During clinical trials, iloprost was used concurrently with anticoagulants, diuretics, cardiac glycosides, calcium channel blockers, analgesics, antipyretics, nonsteroidal anti-inflammatories, corticosteroids, and other medications. Intravenous infusion of iloprost had no effect on the pharmacokinetics of digoxin. Acetylsalicylic acid did not alter the clearance (pharmacokinetics) of iloprost.
