Is it safe to take high doses of vitamin E?
Age-Related Eye Disease Study (AREDS) researchers say it is unclear if the possible increased risk associated with very high doses — 500 IU to 2000 IU — of vitamin E applies to people taking 400 IU. An increased risk of mortality was not found among those taking about 400 IU of vitamin E. The National Institutes of Health Office of Dietary Supplements has a fact sheet on vitamin E that summarizes the research on vitamin E and different chronic diseases.