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Is it reasonable to assume that gabapentin can cause significant drug interactions or side effects?

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Is it reasonable to assume that gabapentin can cause significant drug interactions or side effects?

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Gabapentin is not significantly metabolised and is mainly excreted in the urine, is known for having a relatively low side effect profile, but why would it cause a reaction in a patient being treated for neuropathic pain Additional Details:No quotes from wikipedia please, it is not a reliable source

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