Is it really possible to revert “old” cells into “young” ones again?
Technically yes, but we still do not know how far we can take this. Thus, if cells are completely senescent it may not be possible to get them to grow again even if we could re-elongate the telomeres. However, if telomeres are rate limiting for growth, as we believe, then only a few divisions may be needed to reset the clock. Since all of our cells do not age at the same rate, we believe there will not be a technical barrier to reset the telomere clock in human cells that we can grow in the laboratory.