Is it possible use TRANSIL beads in different pH environments?
Absorption of an orally administered drug is closely linked to the pH value of the monitored compartment. The gastrointestinal fluid’s pH differs vastly along the passage through the gastrointestinal tract. Hence, total absorption and thus bioavailability depends upon permeability rates of the full range of ionization stage of a drug. TRANSIL Intestinal Absorption kits allow the determination of membrane permeability in a range from pH 3 to 11. Thus, the TRANSIL technology allows estimation of membrane permeability across the full physiologically relevant pH range.
