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Is it possible to have an application receive a moderate score for Significance yet receive a very strong Overall Impact score?

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Is it possible to have an application receive a moderate score for Significance yet receive a very strong Overall Impact score?

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One can envision such scenarios. For example, a talented investigator in a very strong environment proposes a highly innovative and very sound approach to address a generally important problem (e.g., breast cancer). However, the proposed project will be relevant to only a narrow area within the larger field of breast cancer research, thus reducing its Significance. Nevertheless, the Overall Impact score could still be strong since the strengths of the project in the other core review criteria give this work the potential to have a sustained, powerful influence on that part of this important field.

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