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Is it possible to demonstrate a 4-fold rise in titer between paired serum samples (acute and convalescent) among cases of mumps with a history of 1 or 2 doses of MMR?

April 26, 2017acute Convalescent demonstrate paired possible Rise samples serum titer

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Is it possible to demonstrate a 4-fold rise in titer between paired serum samples (acute and convalescent) among cases of mumps with a history of 1 or 2 doses of MMR?

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It may not be possible. In vaccinated persons, the existing IgG will begin to rise soon after exposure and infection. At the time of onset of symptoms and collection of the acute serum, the IgG may already be quite elevated, and obviate the 4-fold rise observed in convalescent serum specimen.