Is it possible to compare the effects of free (non-encapsulated) clodronate with those of liposome encapsulated clodronate in vivo?
Since the half life of clodronate in vivo is in the order of 15 minutes, there is quite a difference between injection of a high dose of free clodronate at once, which will then be reduced to half of its original value each 15 minutes AND injection of the same dose in liposomes which will be released from dead macrophages slowly. In the first case there is a high concentration that will be reduced rapidly. In the second case there is a much lower concentration that will be maintained for a longer period of time.
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