Is it possible that a benefit for colorectal cancer will emerge if a low fat dietary pattern is followed for a longer time?
Colorectal cancer can take decades to develop, and is thought to go through a stage of polyp or adenoma first. The reduced rates of self-reported polyp or adenoma in the Dietary Change group may result in delayed benefits in risk of colorectal cancer. A 5-year extended follow-up in these participants is ongoing and may elucidate this, even though the intervention phase of the DM Trial has ended and women are not being instructed to maintain their original dietary assignment (usual or low-fat dietary pattern).