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Is it okay to take either Cimetidine or Amitriptyline with Beta-blockers that I need to take for my migraines?

April 26, 2017amitriptyline beta-blockers cimetidine migraines

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Is it okay to take either Cimetidine or Amitriptyline with Beta-blockers that I need to take for my migraines?

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It is always a problem in taking and combining tablets. Whilst Cimetidine has been around for a very long time and is often used in combination with Beta-blockers, I would be hesitant about recommending Amitriptyline in combination with Beta-blockers. Amitriptyline is a sedative and Beta-blockers also have a role in slowing down the heart rate which can produce a sedative effect. I would therefore certainly be hesitant about recommending a combination of these two.