Is it necessary to rotate from quat sanitizers, chlorine and other types of sanitizers from time to time due to bacteria developing resistance?
There is no scientific literature to support this conclusion. This has generally been stated by the scientific community and more recently by the EPA in recent proposed rule on antimicrobial sanitizers and disinfectants. An antibiotic is designed to enter the living host and target a specific cell keying on a particular site. The antibiotic’s mode of action is to target the disease organisms while not affecting the normal cells. It’s very selective in its activity. Disinfectants like quaternary ammonium chlorides are non-specific in their attack. They attach to anything anionic or negatively charged such as the bacterial protein, which surrounds the bacteria. The quat by surrounding the bacteria disrupts the charges on the cell wall and the cell is killed. Because of this mode of action, antimicrobial resistance is improbable.
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