Is it likely that legitimate messages will be misidentified as spam and deleted?
It’s possible, although Spam Control has a low rate of misidentification. If you’re concerned about this, you can choose Tag and Deliver, whereby no messages are ever deleted–although they all go to your mailbox, including actual spam. You can choose to set up your own filters to move them to another folder or you can use the Cautious policy, in which all messages identified are quarantined for 10 days before they are deleted. This gives you time to review the contents while still reducing spam. You can then release to your inbox any legitimate messages that get quarantined as spam.