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Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma?

April 26, 2017center CNS intrathecal lymphoma methotrexate National necessary primary PubMed treatment

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Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma?

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Systemic high-dose methotrexate (HD-MTX) is the most effective chemotherapeutic agent in the treatment of primary central nervous system lymphoma (PCNSL). Leptomeningeal involvement is common and intrathecal methotrexate (IT-MTX) is frequently used in combination with HD-MTX, but its benefits are not established. Using a case-controlled retrospective study, matching patients treated with HD-MTX with or without IT-MTX, we found no difference in survival, disease control, or neurotoxicity.