Is incomplete 076 ACTG protocol useful in reducing vertical HIV-1 transmission?
INTRODUCTION: ACTG 076 protocol decreased HIV vertical transmission from 25% to 8%. Since 1995 it was initially offered to the HIV-1 infected pregnant women in Argentina. However, different factors, make a full compliance to the regimen a difficult matter. OBJECTIVES: To evaluate HIV-1 vertical transmission when incomplete ZDV treatment was prescribed. METHODS: Records of 95 children born to HIV-1 infected mothers were analyzed. In order to assess vertical transmission 24 mothers and their corresponding children with complete treatment (CT), 17 mothers with incomplete treatment (IT) and 54 with no treatment (NT) were compared. Treatment was considered incomplete when women were enrolled after week 34 of gestation and/or intravenous ZDV was not administered, and/or the baby did not received the ZDV. RESULTS: Transmission was 12.5% for CT, 41% for IT and 31.5% for NT. Significant differences (p = 0.03) in decreasing perinatal transmission were observed between the IT versus CT groups wit
