Is hypnotic withdrawal facilitated by the transitory use of a substitute drug?
Author(s): Lemoine P, Ohayon MM Affiliation(s): Unite Clinique de Psychiatrie Biologique, Bron, France. Publication date & source: 1997-01, Prog Neuropsychopharmacol Biol Psychiatry., 21(1):111-24. Publication type: Clinical Trial; Randomized Controlled Trial 1. PURPOSE: Long-term consumption of hypnotics may lead to various side-effects, including impaired daytime and cognitive functioning and increased risk of accidents. Unfortunately, few guidelines exist for physicians to apply when attempting to withdraw hypnotics from patients. This study investigated whether withdrawal is facilitated by using zopiclone as a substitute drug and evaluated abrupt and gradual substitution techniques. 2. METHODS: This open, multicentre and randomized study involved 1,002 male and female outpatients aged 18 years or over recruited by psychiatrists in Lyon, France. Patients had a mean age of 44 years, and 65.9% were women. Outpatients were chronic insomniacs being treated with a hypnotic for at least t
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- Is hypnotic withdrawal facilitated by the transitory use of a substitute drug?
