Is HMB More than a Hyped Leucine Derivative?
Beta-hydroxy-beta methylbutyrate (HMB) is a purported anti-catabolic agent. HMB is a downstream metabolite of the branched chain amino acid leucine. A recent meta-analysis concluded that HMB along with creatine are two dietary supplements that have substantial evidence indicating a positive effect on lean mass accretion when used with resistance exercise.[15] However, the meta-analysis and most of the studies published on HMB have been conducted by the patent holder(s) and/or staff of the company who distributes HMB (MTI Biotech). Independent studies have found either no effect for enhancing lean body mass or only minor protective effects against stress induced muscle damage (via mitigation of creatine phosphokinase and/or lactate dehydrogenase: CPK, LDH). More research is needed in order to determine if there is a true benefit for aerobic (no current research exists for examining the effect of HMB on time to exhaustion or respiratory quotient during exercise) or for anaerobic athletes
