Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system?
Ann Neurol. 2007 Nov;62(5):493-503. OBJECTIVE: Subjects with severe hemiplegic cerebral palsy have increased ipsilateral corticospinal projections from their noninfarcted cortex. We investigated whether their severe impairment might, in part, be caused by activity-dependent, competitive displacement of surviving contralateral corticospinal projections from the affected cortex by more active ipsilateral corticospinal projections from the nonaffected cortex, thereby compounding the impairment. METHODS: Transcranial magnetic stimulation (TMS) characterized corticospinal tract development from each hemisphere over the first 2 years in 32 healthy children, 14 children with unilateral stroke, and 25 with bilateral lesions. Magnetic resonance imaging and anatomic studies compared corticospinal tract growth in 13 patients with perinatal stroke with 46 healthy subjects. RESULTS: Infants with unilateral lesions initially had responses after TMS of the affected cortex, which became progressively
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- Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system?
