Is having Stevens-Johnson syndrome in the past a contraindication to getting the smallpox vaccine?
Having Stevens-Johnson syndrome (SJS) in the past is not a contraindication from smallpox vaccine receipt, if there are no other contraindications presently to the antibiotics in the vaccine (polymyxin B sulfate, streptomycin sulfate, neomycin sulfate). SJS is an idiosyncratic vesicular mucocutaneous eruption, which may be triggered by medications or infectious agents. Erythema multiforme (E. multiforme) is a mild form of SJS that can range from spots to sores. With SJS a patient has a rash of sores over much of the body and feels sick. E. multiforme usually occurs as a reaction to: infections, such as infections caused by the herpes simplex virus, some medicines, such as sulfa drugs and the seizure medicine phenytoin (Dilantin).