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Is GSTM1 Related to Pulmonary Fibrosis in Asbestos Exposed Workers?

April 26, 2017asbestos Environmental Fibrosis pulmonary Washington Workers

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Is GSTM1 Related to Pulmonary Fibrosis in Asbestos Exposed Workers?

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Occupational and Environmental Medicine, MPH Preceptor: Timothy Takaro, MD, MPH, MS Background: Asbestos continues to be a public health problem today. There does not appear to be an equal dose response across all individuals exposed to asbestos. Host susceptibility must be important in determining who will develop asbestos related disease. Glutathione S-transferases (GST) are a family of conjugating enzymes that catalyze the detoxification of a variety of potentially cytotoxic electrophilic agents. The glutathione S- transferase Mu class in humans is polymorphic. A cross sectional study using 220 subjects from asbestos and lung cancer study will be used to identify an association between GSTM1 null genotype and asbestos related pulmonary disease. Methods: The 220 study subjects were selected from the Beta-Carotene and Retinol Efficacy Trail (CARET) cohort due to the availability of polymorphism data, lung function (spirometry) and chest x-ray data. The 220 subjects were divided into 2