Is glucocorticoid-induced osteonecrosis after kidney transplantation related to osteoporosis?
Email: alpersoy{at}uludag.edu.tr’ + u + ‘@’ + d + ”//–> Sir, Osteopenia and osteonecrosis (ON) cause important long-term morbidity in renal transplant (Tx) recipients with increasing incidences because of longer graft survival and related drug exposure. A 38-year-old woman who started on haemodialysis in November 2001 had a renal Tx from a live relative in March 2003 due to chronic pyelonephritis with vesicoureteral reflux related end-stage renal disease. She had persistent secondary amenorrhoea 2 months before dialysis treatment. Throughout this period she had calcitriol and phosphorus binders for controlling secondary hyperparathyroidism. Her pre-Tx serum parathyroid hormone (PTH) was 73.2 pg/ml and body mass index (BMI) was 18.4 kg/m2. Post-Tx immunosuppressive treatment was prednisolone (500 mg initially, then 30 mg/day), tapered to 25 mg/day by post-operative day 14, mycophenolate mofetil (2 g/day), cyclosporin (CsA; 100 mg/d) and daclizumab (a dose of 1 mg/kg, totalling five do
Related Questions
- Is glucocorticoid-induced osteonecrosis after kidney transplantation related to osteoporosis?
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- What factors would prevent a patient from being a good candidate for kidney transplantation?
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