Is GI Prophylaxis Needed for Dual Antiplatelet Therapy?
Patients on dual antiplatelet therapy can develop both upper and lower GI bleeding. GI hemorrhage is associated with an increased mortality rate, a greater need for surgery, blood transfusions, a prolonged length of hospital stay, and increased overall healthcare costs. Although upper GI bleeding can be prevented with appropriate prophylaxis, there is no effective prophylaxis for lower GI bleeding. Prophylactic acid-suppressive therapy is beneficial in the prevention of upper GI complications. Two major classes of protective agents are (1) H2 antagonists and (2) proton pump inhibitors (PPIs). H2 antagonists reversibly block H2 receptors on the basolateral membrane of gastric parietal cells.17 Until the early 1990s, H2 antagonists were the mainstay of pharmacotherapy for the prevention and management of upper GI bleeding. Between 1984 and 2000, 32 randomized controlled trials compared H2 antagonists with placebo.18 Agents evaluated in these studies included cimetidine, ranitidine, and f
Related Questions
- What other dual antiplatelet therapy duration trials are being conducted? How is the DAPT Study different from the others?
- What are the current protocols that you have been using for dual antiplatelet therapy, how many months normally?
- How dose the Dual Therapy of Amycordial and Amreeplus benefit in PCOS related infertility?
