Is endogenous opioid system involved in non-opioid analgesics tolerance?
Author(s): Tsiklauri N, Gurtskaia G, Tsagareli M Affiliation(s): Department of Neurophysiology, Beritashvili Institute of Physiology, Tbilisi, Georgia. Publication date & source: 2006-08, Georgian Med News., (137):121-5. Publication type: Recent investigations using metamizol and lysine-acetylsalicylate have shown that these non-opioid analgesics produce central anti-nociceptive effects probably through neural substrates that also support the analgesic effects of opiates. The aim of this study was to examine whether a clinically relevant approach, e.g. systemic administration of analgine, ketorolac and xefocam causes tolerance to them, and cross-tolerance to morphine. The experiments were carried out on experimental and control rats with saline by the model of tail-flick reflex to the stimulation of focusing light. Latency increase of this reflex indicates the degree of antinociception. This study of non-opioid analgesic effects on the latency of tail-flick reflex in rats has shown tha
