Is dopamine administration possibly a risk factor for delirium?
OBJECTIVE: We explored the possibility that the administration of intravenous dopamine increases the risk for delirium as manifested by need for haloperidol. DESIGN: This study was based on a retrospective analysis. To examine the contribution of dopamine in the prediction of need for haloperidol, a multivariate logistic regression model was used. SETTING: University hospital. PATIENTS: All inpatient admissions to Stanford University Hospital over a 1-year period (n = 21,844). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Dopamine administration was associated with nearly a tripling of the odds of subsequent need of the antipsychotic drug (chi-square = 108, df = 1, p =.0001, odds ratio = 2.89), even after intensive care unit admission and diagnostic related group weight were considered as indicators of severity of illness. Even when analysis was limited to patients seen in the intensive care unit setting (n = 3,308), dopamine administration remained a very strong risk factor for
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