Is Developmental Ganglion Cell Loss in Hirschsprung Disorders Inherently Linked to Myofiber Hypercontractility?
Abstract: Systems of participation in the development of a state of essential aganglionosis of Hirschsprung’s type might primarily relate to a segmental complex of maldevelopmental processes ranging from bowel wall musculature to related vasculature to systems of asynchronized patterns of innervation and of disturbed trophic influence.The distal spastic segment of aganglionic bowel would be associated with the immediately proximal dilated bowel segment in terms particularly of failed continuity of the neural levels of innervating networks that necessarily impair even transformation of muscle wall tone and segmenting contractions to propulsive peristalsis of such bowel segments. It is in terms of such a primary segmentation of the disease process in Hirschsprung’s that one might consider different schemes of potential developmental progression resulting in aganglionosis of the bowel. Even with regard, however, to a failed innervation pathway of bowel segments in Hirschsprung’s, one woul
