Is Depo-Provera contraindicated in the women with a history of venous thrombo-embolic disease?
No. Depo-Provera can be used even if a woman has a past history of venous thrombo-embolism. Progestins do not appear to increase the risk of thrombosis or thrombophlebitis. All women with a past history of a thrombotic event can use Depo-Provera, whereas many of these individuals would be advised not to consider combined (estrogen/progestin) oral contraceptives.
