Is Clinical Follow-up and Early Intervention Beneficial?
Hyperlipidemia is known to be a risk factor in cardiovascular disease. Hypothyroidism is thought to increase the risk of hyperlipidemia. Will serum lipid levels decrease in SH patients with hypercholesterolemia who are treated with thyroid hormone? Tanis et al (19) in their multi-studies review stated that substitution of thyroid hormone in patients with SH and hypercholesterolemia reduced total serum cholesterol levels by an average of 6%. Considerations noted in their review of these intervention studies are: • An overestimation of the effect of thyroid substitution on the lipid profile may have been affected by dose oversubstitution resulting in TSH levels falling to below normal, however in most of the studies, the dose was titrated to achieve a euthyroid state. • An underestimation of the effect of thyroid substitution on the lipid profile may have been affected by the short duration of treatment in some studies, although in most of the studies patients were treated for longer tha
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