Is chronic fatigue syndrome a contraindication for pre-event vaccination?
Persons with chronic fatigue syndrome (CFS) do not have an immunosuppression detectable in laboratory tests and CFS in itself is not a contraindication. However, persons with CFS sometimes suffer exacerbations of their symptoms following viral infections. While there are no prior data, it is possible that disease symptoms in a person with CFS could increase after smallpox vaccination. Persons with CFS may want to discuss their individual situation with their treating physician before vaccination.