Is chemotherapy beneficial for patients with HRPC?
Patients with HRPC may be offered treatment with docetaxel given at a dose of 75 mg/m2 every 3 weeks combined with prednisone given at a dose of 5 mg twice daily. The combination of docetaxel and estramustine is not recommended given the increased risk of adverse events. Asymptomatic patients with HRPC who refuse docetaxel/prednisone are preferably treated with watchful waiting and symptom management. 6.2.5 Is treatment with bisphosphonates beneficial in patients with HRPC? Intravenous nitrogen-containing bisphosphonates may be used for patients with HRPC and bone pain due to skeletal metastases. Psychosocial Care It is advisable to assume that men with prostate cancer have specific psychosocial issues arising from disease- or treatment-related sexual dysfunction, urinary symptoms, gastrointestinal symptoms, and the slow course of the disease. Men with prostate cancer should be provided with sufficient counselling regarding the disease, treatment options, and the possible side effects
