Is CDI transmittable from father to son? * Will the children of the patient be born suffering from or get sick with CDI?
CDI can result from at least two kinds of genetic mutations. The most common one affects both males and females and can be transmitted from father to son, or father to daughter. On average, about half the children will be affected. The other type of familial CDI is due to a mutation on the x-chromosome. It affects only males and cannot be passed from father to son. It can be passed to a daughter but she will not get DI because the effect of the mutation is prevented by the good gene on her other x-chromosome (males have only one). However, she can pass it to her son who will get CDI. The genetic forms of CDI usually begin in the first 10 years of life. If the CDI did not start until later, it is probably not genetic unless the patient has other affected relatives.
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