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Is Bone Marrow Transplantation the Best Option for Most Children with SAA?

April 26, 2017best blood bone children marrow option SAA transplantation

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Is Bone Marrow Transplantation the Best Option for Most Children with SAA?

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Hematopoietic stem cells are immature cells, which can give rise to all cells in blood. The best donor of the stem cells is a brother or sister “matched” on the basis of tissue typing. Before infusion of donor stem cells, patients receive chemotherapy and radiation to suppress the patient’s abnormal BM and to allow the new stem cells to grow and multiply in the recipient. When the matched sibling donor is not available, stem cells can be obtained from an unrelated donor’s matched bone marrow, circulating blood or umbilical cord blood. BMT is the only current treatment that provides a cure for children with aplastic anemia. BMT from a matched sibling donor should be recommended to all SAA patients who have one. BMT from an alternative donor should be recommended to all patients who have not responded to drug immunosuppressive therapy, or who have had a recurrence of their disease.