Is Basal Microvascular Permeability Determined by PKA Activity?
Jianjie Wang and Virginia H. Huxley Medical Physiology and Pharmacology, National Center of Gender Physiology, University of Missouri-Columbia, MA415, Health Science Biulding, University of Missouri School of Medicine, Columbia, MO, 65212 ABSTRACT Sex-specific differences have been shown to exist in cardiovascular health and disease. Little is known, however, about the role of sex in the regulation of microvascular exchange, particularly microvessel permeability. Previously we have reported that basal permeability (Ps) to albumin of venules isolated from abdominal skeletal muscles was about 2-fold higher in adult male (AM) than adult female (AF), juvenile male (JM), or juvenile female (JF) rats. Further Ps did not differ among AF, JM and JF. It has been demonstrated in frog and rat mesentery that protein kinase A (PKA) played a dominant role in the maintenance of basal microvessel permeability. In this model, the PKA activity was inversely related to Ps. Accordingly, we hypothesized th
Related Questions
- If a Hopkins physician earns credit elsewhere by attending or participating in a CME activity, is Hopkins going to track these credits for him/her?
- Does physical activity have a role in preventing and treating diabetic microvascular complications?
- Is Basal Microvascular Permeability Determined by PKA Activity?
