Is anything known about why some persons require higher doses of thyroid hormone than others?
Factors that influence requirements for thyroid hormone include body weight, hormonal status (menopause, pregnancy), and ingestion of iron, calcium and excess soy. Some individuals exhibit genetic differences in their metabolic conversion of T4 to T3, which can also produce subtle influences on thyroid hormone replacement requirements. See TYPE 2 DEIODINASE POLYMORPHISM (THR92ALA) PREDICTS L-THYROXINE DOSE TO ACHIEVE TARGET TSH LEVELS IN THYROIDECTOMIZED PATIENTS J Clin Endocrinol Metab. 2007 Dec 11; Similarly, patients with autoimmune gastritis appear to require higher doses of thyroxine replacement therapy L-THYROXINE (L-T4) REQUIREMENT IN PATIENTS WITH AUTOIMMUNE HYPOTHYROIDISM AND PARIETAL CELL ANTIBODIES J Clin Endocrinol Metab.
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