Is an urticarial rash that develops after a previous smallpox vaccination a contraindication to subsequent smallpox vaccine?
Generalized urticaria is a contraindication to smallpox vaccination if it occurs within a few hours of vaccination (because it could be the result of an allergy). If it occurs days after vaccination, it is not a contraindication. Urticarial rashes are common and the majority of them are self-limiting. Often the urticaria is a manifestation of an allergic IgE mediated reaction. Urticaria frequently occurs during an anaphylactic response although other signs that would be present include flushing, hypotension, syncope, respiratory blockage and abdominal symptoms. Persons with a history of urticaria but no other sign of anaphylaxis after a previous smallpox vaccination could probably be re-vaccinated without severe consequences. If there are questions or concerns about the history or the risks versus the benefits of vaccination in a pre-event setting, a referral to an allergist may be prudent.
Related Questions
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- Is an urticarial rash that develops after a previous smallpox vaccination a contraindication to subsequent smallpox vaccine?
