Is Abraxane® (nanoparticle albumin-bound [NAB] paclitaxel) as good as Taxotere® (docetaxel)?
NAB paclitaxel has been compared to docetaxel in a recent randomized phase II trial. The weekly schedule of NAB paclitaxel has been shown to be more efficacious compared with every 3 weeks for docetaxel. A pivotal phase 3 trial comparing NAB paclitaxel weekly to every 3 weeks for docetaxel is planned. However, both agents have been compared with Taxol® (paclitaxel) in separate randomized studies. In the trial where NAB paclitaxel was compared with paclitaxel, NAB paclitaxel could be given in a higher dose (260 mg versus 175 mg/m2), which resulted in more shrinkage of tumors and longer time to progression. Although toxicity to nerves was observed more frequently with NAB paclitaxel, it was shorter lived. This was believed to be due to the lack of the toxic solvent Cremophor (castor oil), which is used with paclitaxel to make it soluble. A separate trial comparing docetaxel with paclitaxel showed docetaxel was better for shrinking tumors, time to progression, and overall survival at the
NAB paclitaxel has been compared to docetaxel in a recent randomized phase II trial. The weekly schedule of NAB paclitaxel has been shown to be more efficacious compared with every 3 weeks for docetaxel. A pivotal phase 3 trial comparing NAB paclitaxel weekly to every 3 weeks for docetaxel is planned. However, both agents have been compared with Taxol® (paclitaxel) in separate randomized studies. In the trial where NAB paclitaxel was compared with paclitaxel, NAB paclitaxel could be given in a higher dose (260 mg versus 175 mg/m2), which resulted in more shrinkage of tumors and longer time to progression. Although toxicity to nerves was observed more frequently with NAB paclitaxel, it was shorter lived. This was believed to be due to the lack of the toxic solvent Cremophor (castor oil), which is used with paclitaxel to make it soluble. These studies have been completed in patients with metastatic disease. A separate trial comparing docetaxel with paclitaxel showed docetaxel was better
Related Questions
- Can Abraxane® (nanoparticle albumin-bound [NAB] paclitaxel) be given instead of Taxol® (paclitaxel) in the postoperative treatment of cancer?
- Is it true that I receive a higher dose of Taxol® (paclitaxel) if I receive Abraxane® (nanoparticle albumin-bound [NAB] paclitaxel)?
- Is Abraxane® (nanoparticle albumin-bound [NAB] paclitaxel) as good as Taxotere® (docetaxel)?
