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In the last allowable resubmission opportunity, my application did not receive a fundable score. May I submit it as a new application if I remove the aim that the reviewers didn like?

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In the last allowable resubmission opportunity, my application did not receive a fundable score. May I submit it as a new application if I remove the aim that the reviewers didn like?

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No. Removal of an aim in response to a previous review does not constitute a new application or a new line of research. The main objective of the science is essentially the same and it is NIH policy that the same project may not be reviewed more than the maximum number of times. An application in the same general area of research but with different components (e.g., aims, methods, outcomes) may be sufficiently different. A new application is one that presents a new line of research and one that has not been previously peer reviewed by the NIH.

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