In first order kinetics, how could these drugs reach Css although the capacity of the body to eliminate them is unlimited?
In First order kinetics: the rate of elimination is directly proportional to the concentration i.e. if the drug concentration in the blood increases, the rate of elimination also increases. With repeated drug administration the concentration of the drug in plasma increases and subsequently, the rate of elimination increases till it can eliminate the entire dose administered. At this point, the rate of elimination is equal to the rate of administration and the drug concentration in blood will not increase. For example suppose a drug is given every half life and after that each dose increases the drug concentration by 16 mg/L: Immediately after the first dose the conc. is 16 Before the second dose (after one t1/2) the conc. is 8 After the second dose the conc. is 8 +16 =24 Before the third dose (after two t1/2) the conc. is 24/2=12 After the third dose the conc. is 12 +16 =28 Before the fourth dose (after three t1/2) the conc. is 28/2=14 After the fourth dose the conc. is 14 +16 =30 Befo
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