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I’m afraid of using fertility medications because of the risk of having quadruptlets. What is the actual risk?

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I’m afraid of using fertility medications because of the risk of having quadruptlets. What is the actual risk?

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It is true that medications designed to help a woman ovulate can increase her chances of having a multiple gestation. Taking the oral medication clomiphene leads to a 7% chance of twins. The risk of having greater than twins is very low (about 1 in 200). The injectable gonadotropin medications have been reported to produce twins in up to 20% of pregnancies. Triplets can occur in up to 5% of pregnancies. Having greater than triplets from the injectable medications is rare (less then 1% of pregnancies). In-Vitro Fertilization results in up to 40% twins. However, we are returning a limited number of embryos to the uterus (often only 2); and thus, the chance for triplets ranges from 0-10% depending on the number of embryos transferred.

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