If mini stem-cell transplants are so much easier on the patient, why are myeloablative transplants still being done?
Unfortunately, mini or non-myeloablative transplants can’t be used in every situation. This type of treatment works best for treatment of certain diseases and is not effective for other diseases, depending on whether immune cells of the donor can eliminate malignant cells in the recipient. Immune cells of the donor are most effective when the patient has a low number of malignant cells. In order to have a successful outcome, the patient’s disease might have to be in remission before a non-myeloablative transplant. Clinical trials are in progress to find out whether mini or non-myeloablative transplants can be successful for patients who do not have a fully HLA-matched donor. Further research is needed to determine whether mini-transplant is a safe and effective treatment for all types of disease that are treated by stem-cell transplant. For more information, go to: • http://www.ibmtindy.com/intouch/i1v1/i1v1.
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