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If endodontic treatment is generally successful, why do certain endodontically treated teeth fail and what are the causes of such failures?

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If endodontic treatment is generally successful, why do certain endodontically treated teeth fail and what are the causes of such failures?

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A. Root canals fail due to microleakage and bacterial infection. The precise cause of endodontic failures can be attributable to inadequacies in three-dimensional cleaning, shaping and obturation. Additionally, failures occur because of missed canals, iatrogenic events, radicular fractures, or re-infection of the root canal system when the coronal seal is lost after the completion of root canal treatment. Regardless of the etiology, the sum of all causes is leakage, bacterial contamination or re-contamination.

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