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If an investigator has already submitted an application for a different mechanism, may the investigator apply for a Challenge Grant with the same scientific aims?

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A1. The long-standing NIH policy that no application essentially identical to a currently pending application will be accepted remains in effect. Applicants will have to withdraw any such application prior to submitting a Challenge Grant application. The NIH policy that all applications submitted in response to an RFA are considered to be new applications continues to apply, as does the policy that unsuccessful responses to RFAs may be submitted as new applications in response to any other NIH Funding Opportunity Announcement (FOA) (see: http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-03-019.html). A previously unsuccessful submission to any NIH FOA may be submitted as a new application in response to the Challenge Grant RFA, but it may not include an Introduction indicating how previously received criticisms have been addressed. The Challenge Grant RFA provides for only one receipt date and specifically states that resubmission of Challenge Grant applications will not be accep

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