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If a drug abuser takes a stimulant and a depressant, will the effects cancel out?

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If a drug abuser takes a stimulant and a depressant, will the effects cancel out?

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marijuana isnt a depressant its a halucinogen but no when im on e i smoke allot of weed it doesnt cancel out the effects the only time that happends is when you drink alchohol and snort coke then it evens out marijuana doesnt kill braincells it jut makes it harder for them to grow back, ecstasy doesn kill braincells either,

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