I would like to run simulations for a specific disease state or a physiology affected by prior administration of certain drug (e.g., elevated stomach pH). What can I do?
GastroPlus comes with a set of default gut and full body (PBPK) physiological parameters for healthy subjects. However, all parameters in these physiologies can be adjusted to the condition you would like to simulate. As long as you know what parameters are affected by the specific condition (e.g., elevated stomach pH, increased fat content, decreased renal function), you can adjust the physiological parameters and save this user-defined physiology for use in your simulations.
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