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I was recently put on ketoconazole and hydrocortisone for HRPC (hormone-refractory prostate cancer). Do I need to be careful if Im on other medications?

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I was recently put on ketoconazole and hydrocortisone for HRPC (hormone-refractory prostate cancer). Do I need to be careful if Im on other medications?

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Yes. Check with your pharmacist because they have computers to look at interactions with any drugs you are taking. There are two very important ones that anyone taking ketoconazole should be aware of. It can prolong the effect of CoumadinĀ® (warfarin), and therefore frequent pro-time/international normalized ratios (INRs) need to be checked when starting and stopping ketoconazole. There is also a very dangerous interaction when one is on ZocorĀ® (simvastatin). This combination can cause muscle death and kidney failure.

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