i read somewhere in teh text that all values are relative to the inside >of the cell…what does that mean?”
…we are always interested in the internal voltage of the cell so the equations for the Nernst are set up that way >and does that fact affect the signs on the values given by >nernst and goldman” …your text book runs through the equation as it should be viewed with the internal ion concentrations as the denominator of the formula (e.g., for K+, that gives you approx 1/10 which logs out to -1 which gives you a E(K+) of -57 mV. > I thought they knew the Voltage activated sodium channel > closing mechanism. There is a sequence of three amino acids – in each > domain of the channel (thus, making total of four tripeptide sequence) > that is involved in sodium channel inactivation. I might be able to get > the reference if you want. They know the structures within the channel but the activating mechanism is still fuzzy, it might be via intra-lipid layer sensing particles but those haven’t been identified yet.
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