I lost the review for the pH and pKa material. Are they at the web site?
Many of the class overheads for pH are at the web site. The Appendix to Ch. 3 of Stryer covers this in detail. ***** Q: I know you said you’d like us to look over the covalent inhibition slides before the test but they’re pretty difficult to read, especially the last one. I was just curious if you would be asking any specific questions from these slides on the test or should we just know about phosphate’s inhibition of serine esterases? A: Since I didn’t lecture on inhibitors I cannot expect you to know _details_ from a figure I didn’t explain. (With material from the text it might be different.) Phosphate per se is not important; what’s important is the fact that one can design a substrate analogue (a small organic molecule which resembles part of the natural substrate) which reacts with the enzyme to make a covalent intermediate, but the intermediate is chemically stable and cannot be removed like the normal substrate. Q: Could you please post the lecture slides over the lysozyme rea
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