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I hear AMS analysis is more expensive than LC-MS, so is an IVPK study more expensive than a traditional absolute bioavailability study?

April 26, 2017AMS analysis bioavailability expensive hear ivpk lc-ms study traditional

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I hear AMS analysis is more expensive than LC-MS, so is an IVPK study more expensive than a traditional absolute bioavailability study?

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No, it is significantly less expensive. There is no need to conduct safety toxicology which will save typically $0.5 million plus the savings on intravenous dose formulation which can cost hundreds of thousands of dollars. In addition, it is possible to turn an IVPK around in about 4 months and with some drugs this is less time than it takes to develop an intravenous dose formulation.