I have read articles that state despite high specificity of asialotransferrin, its sensitivity is too low to make it a useful marker for alcohol abuse. How can I effectively use CEoFix CDT Kit?
[top] The article you have seen is no problem for the CE technique or for using the CEoFix CDT kit. This article states that 0-sialo Transferrin is very specific but not sensitive. In fact you have to look first to the 2-sialo Transferrin or the addition of the 0- and 2-sialo Transferrin. With this your specificity is close to 97% and sensitivity 81%. In fact 0-siallo Transferrin will only appear, but not always at higher level of 2-sialo Transferrin. This kit is used very effectively for detection of alcohol abuse throughout Europe and is now being used in North America.
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